What is Mydesktopdefence.com? Mydesktopdefence.com pop-up alerts are a SCAM that uses social engineering methods to trick unsuspecting users into believing the computer is vulnerable to viruses. Scammers use fake alerts to lure the users into installing software they don’t need. Mydesktopdefence.com pop-ups can invade computers, Android/Apple devices when users land on deceptive websites — by